City University of Hong Kong

Laboratory of Nanosensor Imaging in Cell Therapy (NICE-Lab)

Recent Publications

  1. R. S. P. Prabakaran, J. Huang, K. W. Y. Chan*. Deep learning based super resolution for accelerating chemical exchange saturation transfer MRI. NMR Biomed. In Press DOI: 10.1002/nbm.5130. PMID: 38491754. (IF:4.478; Spectroscopy: 6/43=13%, A)
  2. J. Huang#, Z. Chen#, P. C. M. van Zijl, L. H. Law, R. S. P. Prabakaran, S. W. Park, J. Xu, K. W. Y. Chan*. Effect of inhaled oxygen level on dynamic glucose-enhanced (DGE) MRI in mouse brain. Magn. Reson. Med. In Press DOI: 10.1002/mrm.30035. PMID: 38308151.
  3. S. W. Park, J. H. C. Lai, X. Han, V. W. M. Leung, P. Xiao, J. Huang, K. W. Y. Chan*. Preclinical application of CEST MRI to detect early and regional tumor response to local brain tumor treatment. Pharmaceutics2024 In Press DOI: 10.3390/pharmaceutics16010101. PMID: 38258112. (IF: 6.525; Pharmacology & Pharmacy: 30/361=8%, A+)
  4. R. Xiao, J. Li, Y. F. Wong, L. T. Chu, Y. Zhu, L. Wang, M. Wu, D. Zhang, M. Gong, J. H. C. Lai, K. W. Y. Chan, R. Fan, T. H. Chen, Y. Lu. Enhancing detection accuracy via controlled release of 3D-printed microlattice nasopharyngeal swabs. Communications Engineering 2024:3:40.
  5. G. Wang, Y. Zhang, H. K. Kwong, M. Zheng, J. Wu, C. Cui, K. W. Y. Chan, C. Xu, T. H. Chen. On-site Melanoma Diagnosis Utilizing a Swellable Microneedle-assisted Skin Interstitial Fluid Sampling and a Microfluidic Particle Dam for Visual Quantification of S100A1. Advanced Science 2024:11:e2306188. DOI: 10.1002/advs.202306188. PMID: 38417122.
  6. J. Huang, K. W. Y. Chan*. Editorial for “Multi-parametric MRI for evaluating variations in renal structure, function and endogenous metabolites in an animal model with acute kidney injury induced by ischemia repoerfusion”. J Magn. Reson. Imaging 2023 In Press DOI: 10.1002/jmri.29096. PMID: 37881885.
  7. J. Xu, T. Zu, Y. Hsu, X. Wang, K. W. Y. Chan, Y. Zhang. Accelerating chemical exchange saturation transfer imaging using a model-based deep neural network with synthetic training data. Magn. Reson. Med. 2024:91:583-599. DOI:10.1002/mrm.29889.
  8. N. P. B. Au, T. Wu, G. Kumar, Y. Jin, Y. Y. T. Li, S. L. Chan, J. H. C. Lai, K. W. Y. Chan, K. N. Yu, X. Wang, C. H. E. Ma. Low-dose ionizing radiation promotes motor recovery and brain rewiring by resolving inflammatory response after brain injury and stroke. Brain Behav. Immun. 2004:115:43-63. DOI: 10.1016/j.bbi.2023.09.015. PMID: 37774892. (IF: 19.227)
  9. X. Xie, J. Zhai, X. Zhou, Z. Guo, P. C. Lo, G. Zhu, K. W. Y. Chan, M. Yang. Magnetic particle imaging: from tracer design to biomedical applications in vasculature abnormality. Adv. Mater. 2023:Oct 9:e2306450. DOI: 10.1002/adma.202306450. PMID: 37812831.
  10. K. Wang, J. Huang, L. Ju, S. Xu, R. P. Gullapalli, Y. Liang, J. Rogers, Y. Li, P. C. M. van Zijl, R. G. Weiss, K. W. Y. Chan, J. Xu. Creatine mapping of the brain at 3T by CEST MRI. Magn. Reson. Med. 2024:91:51-60. DOI:10.1002/mrm.29876. PMID: 37814487.
  11. G. W. Cheng, I. W. Ma, J. Huang, S. H. Yeung, P. Ho, Z. Chen, H. K. F. Mak, K. Herrup, K. W. Y. Chan, K. H. Tse. Cuprizone drives divergent neuropathological changes in different mouse models of Alzheimer’s disease. bioRxiv 2023:25:2023.07.24.547147. DOI: 10.1101/2023.07.24.547147. Preprint PMID: 37546935.
  12. T. Zhang#, X. Han#, Y. Zhang, H. Tong, D. Qiao, Z. Chen, K. W. Y. Chan*, W. P. Chong*, J. Chen*. Regulatory T cell intravitreal delivery using hyaluronan methyl cellulose hydrogel improves therapeutic efficacy in experimental autoimmune uveitis. Biomaterials Advances 2023:151:213496. DOI: 10/1016/j.bioadv.2023.213496. PMID: 37290283.
  13. Z. Chen, J. Huang, J. H. C. Lai, K. H. Tse, J. Xu, K. W. Y. Chan*. Chemical exchange saturation transfer (CEST) MRI detects myelin changes in cuprizone mouse model at 3T. NMR Biomed. 2023:e4937. DOI:10/1002/nbm.4937. PMID: 36965064. (IF:4.478; Spectroscopy: 6/43=13%, A)
  14. L. H. Law, J. Huang, P. Xiao, Y. Liu, Z. Chen, J. H. C. Lai, X. Han, G. W. Y. Cheng, K. H. Tse, K. W. Y. Chan*. Multiple CEST contrast imaging of nose-to-brain drug delivery using Iohexol liposomes at 3T MRI. J Control. Release. 2023:354:208-220. DOI:10/1016/j.jconrel.2023.01.011. PMID: 36623695. (IF:11.467; Pharmacology & Pharmacy: 12/279=4%, A+)
  15. J. H.C. Lai, J. Liu, T. Yang, J. Huang, Y. Liu, Z. Chen, Y. Lee, G. K. K. Leung, and K. W.Y. Chan*. CEST MRI for longitudinal assessment of intracerebral hemorrhage and deferoxamine treatment at 3T. Stroke. 2023:54(1):255-264. DOI: 10/1161/STROKEAHA.122.040830. PMID: 36416125. (IF:10.170; Clinical Neurology; 14/212=6%, A+)
  16. L. Knutsson, X. Xu, P. C. M. van Zijl, K. W. Y. Chan*. Imaging of sugars using their hydroxyl proton exchange properties. NMR Biomed. 2023:e4784. (Invited Review) (IF:4.478; Spectroscopy: 6/43=13%, A)
  17. R. P. H. Wang, J. Huang, K. W. Y. Chan, W. K. Leung, T. Goto, Y. S. Ho, R. C. C. Chang. IL-1beta and TNF-alpha play an important role in modulating the risk of periodontitis and Alzherimer’s disease. J. Neuroinflammation 2023:20(1):71. DOI:10.1186/s12974-023-0274704. (IF:9.589; Neurosciences; 24/275=8%, A+)
  18. L. Wan, Z. Mao, H. Liu, Y. Xie, F. Lyu, Z. Cao, Y. He, J. Yin, X. Han, K. W. Y. Chan, J. Lu. Direct 4D printing of gradient structure of ceramics. Chem. Eng. J. 2023:465:142804.(IF:15.1; Chemical Engineering: 5/140=3.6%, A+)
  19. S. Chen, Z. Tan, P. Liao, Y. Li, Y. Qu, Q. Zhang, M. Yang, K. W. Y. Chan, L. Zhang, K. Man, Z. Chen, D. Sun. Biodegradable microrobots for DNA vaccine delivery. Advanced Healthcare Materials 2023:12(21):22202921. DOI:10.1002/adhm.202202921 (IF:11.092; Biomedical Engineering: 8/98=8.2%, A+)
  20. P. Xiao, J. Huang, X. Han, J. W. Cheu, Y. Liu, L. H. Law, J. H. C. Lai, J. Li, S. W. Park, C. C. L. Wong, R. H. W. Lam,K. W. Y. Chan*. Monitor Tumor pHe and Response Longitudinally during Treatment using CEST MRI-detectable Alginate Microbeads. ACS App. Mater. Inter. 2022:14(49):54401-54410. DOI: 10.1021/acsami.2c10493. PMID: 36448714. (IF:10.383; Supp. Cover Article)(Materials Science, Multidisciplinary: 47/414=11%, A)
  21. (*)J. Huang, Z. Chen, S. W. Park, J. H. C. Lai, K. W. Y. Chan*. Molecular imaging of brain tumors and drug delivery using CEST MRI: promises and challenges. Pharmaceutics 2022:14(2):451. DOI: 10.3390/pharmaceutics14020451. PMID: 35214183. (IF: 6.525; Pharmacology & Pharmacy: 30/361=8%, A+)
  22. J. Huang, J. H. C. Lai, X. Han, Z. Chen, P. Xiao, Y. Liu, L. Chen, J. Xu, K. W. Y. Chan*. Sensitivity schemes for dynamic glucose enhanced (DGE) MRI to detect glucose uptake and clearance in mouse brain at 3T. NMR Biomed. 2022:35(3):e4640. DOI: 10.1002/nbm.4640. PMID: 34750891. (Cover) (IF:4.478; Spectroscopy: 6/43=13%, A)
  23. (*) J. Huang, J. H. C. Lai, K. H. Tse, G. W. Y. Cheng, Y. Liu, Z. Chen, X. Han, L. Chen, J. Xu, K. W. Y. Chan*. Deep neural network based CEST AREX processing: application in imaging a model of Alzheimer’s disease at 3T. Magn. Reason. Med. 2022:87(3):1529-1545. DOI:10.1002/mrm.29044. PMID: 34657318 (MRM Highlights Pick) (IF: 4.668; Radiology, Nuclear Medicine & Medical Imaging: 18/186=9.7%, A+)
  24. E. C. H. Ma, Pallavi Asthana, G. Kumar, L. Milanowski, N. P. Au, S. C. Chan, J. Huang, H. Feng, K. M. Kwan, J. He, K. W.Y. Chan, Z. Wszolek. Cerebellar glutamatergic system impacts spontaneous motor recovery by regulating Gria1 expression. NPJ Regenerative Medicine. 2022:7(1):45. (IF:14.404; Biomedical Engineering: 9/115=7%, A+)
  25. Z. Han, C. Chen, X. Xu, R. Bai, V. Staedtke, J. Huang, K. W. Y. Chan, J. Xu. D. O. Kamson, Z. Wen, L. Knutsson, P. C. M. van Zijl, G. Liu. Dynamic contrast-enhanced CEST MRI using a low molecular weight dextran. NMR Biomed. 2022; e4649. (IF:4.478; Spectroscopy: 6/43=13%, A)
  26. J. Huang, J. Xu, J. H. C. Lai, Z. Chen, C. Y. Lee, H. K. F. Mak, K. H. Chan, K. W. Y. Chan*. Relayed nuclear Overhauser effect weighted (rNOEw) imaging identifies multiple sclerosis. NeuroImage: Clinical. 2021:32:102867. DOI: 10.1016/j.nicl.2021.102867. PMID: 34751151. (IF: 4.891; Neuroimaging: 5/15=33%, B+)
  27. J. Huang, L. Chen, X. Xu, P. C. M. van Zijl, J. Xu, K. W. Y. Chan*. Relayed nuclear Overhauser enhancement imaging with magnetization transfer contrast suppression at 3T. Magn. Reson. Med. 2021:85(1):254-267. DOI:10.1002/mrm.28433. PMID:32738080 (IF:4.668) (IF: 4.668; Radiology, Nuclear Medicine & Medical Imaging: 18/186=9.7%, A+)
  28. X. Han, J. H. C. Lai, J. Huang, S. W. Park, Y. Liu, K. W. Y. Chan*. Imaging self-healing hydrogels and chemotherapeutics using CEST MRI at 3T. ACS Applied Bio Materials 2021:4(7):5605-5616. DOI: 10.1021/acsabm.1c00411.(IF:3.234; Supp. Cover Article)(Nanoscience & Nanotechnology: 73/138=52%, B)
  29. H. M. Leung, C. H Lau, J. W. Ho, M. S. Chan, T. J. H. Chang, L. H. Law, F. Wang, D. Y. Tam, L. S. Liu, K. W. Y. Chan, C. Tin, P. K. Lo. Targeted brain tumor imaging by using discrete biopolymer-coated nanodiamonds across the blood brain barrier. Nanoscale 2021:13:3184-3193. (IF:8.307; Materials Science, Multidisciplinary: 68/414=16%, A)
  30. R. Sui, L. Chen, Y. Li, J. Huang, K. W. Y. Chan, X. Xu, P. C. M. van Zijl, J. Xu. Whole-brain amide CEST imaging at 3T with a steady-state radial MRI acquisition. Magn. Reson. Med. 2021:86(2):893-906. (IF: 4.668; Radiology, Nuclear Medicine & Medical Imaging: 18/186=9.7%, A+)
  31. J. Huang, P. C. M. van Zijl, X. Han, C. M. Dong, G. W. Y. Cheng, K. H. Tse, L. Knutsson, L. Chen, J. H. C. Lai, E. X. Wu, J. Xu*, K. W. Y. Chan*. Altered D-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose enhanced MRI. Science Advances 2020:6:eaba3884. (IF:14.972; Multidisciplinary: 7/134=5%, A+)

Journal Publications (Selected)

2023


Chemical exchange saturation transfer (CEST) MRI detects myelin changes in cuprizone mouse model at 3T

Chemical exchange saturation transfer (CEST) MRI detects myelin changes in cuprizone mouse model at 3T


Chen Z, Huang J, Lai JHC, Tse KH, Xu J, Chan KWY*

NMR in Biomedicine, 2023, e4937.
Chemical Exchange Saturation Transfer Magnetic Resonance Imaging for Longitudinal Assessment of Intracerebral Hemorrhage and Deferoxamine Treatment at 3T in a Mouse Model

Chemical Exchange Saturation Transfer Magnetic Resonance Imaging for Longitudinal Assessment of Intracerebral Hemorrhage and Deferoxamine Treatment at 3T in a Mouse Model


Lai JHC, Liu J, Yang T, Huang J, Liu Y, Chen Z, Lee Y, Leung KK, Chan KWY*

Stroke, 2023, 54:255–264.
Multiple CEST contrast imaging of nose-to-brain drug delivery using iohexol liposomes at 3T MRI

Multiple CEST contrast imaging of nose-to-brain drug delivery using iohexol liposomes at 3T MRI


Law LH, Huang J, Xiao P, Liu Y, Chen Z, Lai JHC, Han X, Cheng GWY, Tse KH, Chan KWY*

Journal of Controlled Release, 2023, 354: 208-220.

2022


Monitor Tumor pHe and Response Longitudinally during Treatment Using CEST MRI-Detectable Alginate Microbeads

Monitor Tumor pHe and Response Longitudinally during Treatment Using CEST MRI-Detectable Alginate Microbeads


Xiao P, Huang J, Han X, Cheu JWS, Liu Y, Law LH, Lai JHC, Li J, Park SW, Wong CCL, Lam RHW, Chan KWY*

ACS Applied Materials & Interfaces, 2022, 14:54401–54410.
Imaging of sugar-based contrast agents using their hydroxyl proton exchange properties

Imaging of sugar-based contrast agents using their hydroxyl proton exchange properties


Knutsson L, Xu X, van Zijl PCM, Chan KWY*

NMR in Biomedicine, 2022, e4784.
Deep neural network based CEST and AREX processing: Application in imaging a model of Alzheimer’s disease at 3 T

Deep neural network based CEST and AREX processing: Application in imaging a model of Alzheimer’s disease at 3 T


Huang J#, Lai JHC#, Tse K-H, Cheng GWY, Liu Y, Chen Z, Han X, Chen L, Xu J, Chan KWY*

Magnetic Resonance in Medicine, 2022, 87(3): 1529-1545. [Editor Picks & MRM Highlights]. [Code].
Sensitivity schemes for dynamic glucose-enhanced magnetic resonance imaging to detect glucose uptake and clearance in mouse brain at 3 T

Sensitivity schemes for dynamic glucose-enhanced magnetic resonance imaging to detect glucose uptake and clearance in mouse brain at 3 T


Huang J, Lai JHC, Han X, Chen Z, Xiao P, Liu Y, Chen L, Xu J, Chan KWY*

NMR in Biomedicine, 2022, 35(3): e4640. [Cover Article].
Molecular Imaging of Brain Tumors and Drug Delivery Using CEST MRI: Promises and Challenges

Molecular Imaging of Brain Tumors and Drug Delivery Using CEST MRI: Promises and Challenges


Huang J#, Chen Z#, Park S-W, Lai JHC, Chan KWY*

Pharmaceutics, 2022, 14(2): 451.

2021


Relayed nuclear Overhauser effect weighted (rNOEw) imaging identifies multiple sclerosis

Relayed nuclear Overhauser effect weighted (rNOEw) imaging identifies multiple sclerosis


Huang J#, Xu J#, Lai JHC, Chen Z, Lee CY, Mak HKF, Chan KH, Chan KWY*

NeuroImage: Clinical, 2021, 32: 102867.
Imaging Self-Healing Hydrogels and Chemotherapeutics Using CEST MRI at 3 T

Imaging Self-Healing Hydrogels and Chemotherapeutics Using CEST MRI at 3 T


Han X, Lai JHC, Huang J, Park SW, Liu Y, Chan KWY*

ACS Applied Bio Materials, 2021, 4(7): 5605-5616.
Relayed nuclear Overhauser enhancement imaging with magnetization transfer contrast suppression at 3 T

Relayed nuclear Overhauser enhancement imaging with magnetization transfer contrast suppression at 3 T


Huang J#, Han X#, Chen L, Xu X, Xu J, Chan KWY*

Magnetic Resonance in Medicine, 2021, 85(1): 254-267.

2020


Altered D-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI

Altered D-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI


Huang J, van Zijl PCM, Han X, Dong CM, Cheng GWY, Tse K-H, Knutsson L, Chen L, Lai JHC, Wu EX, Xu J, Chan KWY*

Science Advances, 2020, 6(20): eaba3884.
In vivo imaging of phosphocreatine with artificial neural networks

In vivo imaging of phosphocreatine with artificial neural networks


Chen L, Schär M, Chan KWY, Huang J, Wei Z, Lu H, Qin Q, Weiss RG, van Zijl PCM, Xu J*

Nature Communications, 2020, 11(1): 1-10.
CEST MRI detectable liposomal hydrogels for multiparametric monitoring in the brain at 3T

CEST MRI detectable liposomal hydrogels for multiparametric monitoring in the brain at 3T


Han X, Huang J, To AK, Lai JHC, Xiao P, Wu EX, Xu J, Chan KWY*

Theranostics, 2020, 10(5): 2215.

2019


GlucoCEST imaging with on‐resonance variable delay multiple pulse (onVDMP) MRI

GlucoCEST imaging with on‐resonance variable delay multiple pulse (onVDMP) MRI


Xu X, Xu J, Chan KWY, Liu J, Liu H, Li Y, Chen L, Liu G, van Zijl PCM*

Magnetic Resonance Medicine, 2019, 81(1): 47-56.
The effect of the mTOR inhibitor rapamycin on glucoCEST signal in a preclinical model of glioblastoma

The effect of the mTOR inhibitor rapamycin on glucoCEST signal in a preclinical model of glioblastoma


Xu X, Xu J, Knutsson L, Liu J, Liu H, Li Y, Lal B, Laterra L, Artemov D, Liu G, van Zijl PCM, Chan KWY*

Magnetic Resonance in Medicine, 2019, 81(6): 3798-3807.
Elasticity-modulated microbeads for classification of floating normal and cancer cells using confining microchannels

Elasticity-modulated microbeads for classification of floating normal and cancer cells using confining microchannels


Ren J, Li J, Li Y, Xiao P, Liu Y, Tsang CM, Tsao SW, Lau D, Chan KWY*, Lam RHW*

ACS Biomaterials Science & Engineering, 2019, 5(8): 3889-3898.

2018 & Earlier


MRI-detectable pH nanosensors incorporated into hydrogels for in vivo sensing of transplanted cell viability

MRI-detectable pH nanosensors incorporated into hydrogels for in vivo sensing of transplanted cell viability


Chan KWY, Liu G, Song X, Kim H, Yu T, Arifin DR, Assaf AA, Hanes J, Walczak P, van Zijl PCM, Bulte JWM, McMahon MT*

Nature Materials, 2013, 12(3): 268-275.

Conference Proceedings


2022


  1. Chen Z, Huang J, Lai JHC, Tse KH, Chan KWY. Demyelination and remyelination in cuprizone mouse model detected by CEST MRI at 3T. ISMRM, 2022, #4517. [Magna Cum Laude]
  2. Law LH, Huang J, Liu Y, Xiao P, Lai JHC, Chen Z, Chan KWY. Develop CEST-detectable liposomes for nose-to-brain drug delivery. ISMRM, 2022, #0486.
  3. Huang J, Chen Z, van Zijl PCM, Law LH, Pemmasani Prabakaran RS, Park SW, Xu J, Chan KWY. Dynamic glucose enhanced MRI detects glucose-related responses in mouse brain under normoxia and hyperoxia. ISMRM, 2022, #3836.
  4. Pemmasani Prabakaran RS, Chen Z, Lai JHC, Park SW, Liu Y, Huang J, Chan KWY. Single-offset and multi-offset super-resolution for CEST MRI using deep transfer learning. ISMRM, 2022, #3847.
  5. Park SW, Lai JHC, Han X, Huang J, Xiao P, Chan KWY. Developing CEST-detectable liposomal hydrogel for monitoring local brain tumor treatment. ISMRM, 2022, #4286.
  6. Lai JHC, Yang T, Huang J, Liu Y, Lee Y, Chan KWY. rNOE imaging detects distinctive neuropathology in Intracerebral Hemorrhage (ICH) under deferoxamine treatment. ISMRM, 2022, #6084.

2021


  1. Law LH, Xiao P, Huang J, Han X, Chan KWY. CEST Imaging of Nose-to-Brain Drug Delivery using Iohexol liposomes at 3T. ISMRM, 2021, #0720.

2020


  1. Lai JHC, Huang J, Han X, Xu J, Chan KWY. Alzheimer’s Disease identification by an artificial neutral network based on chemicalexchange saturation transfer (ANNCEST) MRI. ISMRM, 2020, #3123.
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